Cytomegalovirus (CMV)

A Comprehensive Guide to Cytomegalovirus (CMV) Detection

The healthcare landscape is consistently abuzz with advancements, aiming to improve patient care. One such development is the introduction of the DiAGSure CMV RT-PCR Detection kit, designed to detect Cytomegalovirus (CMV)— a common virus that can cause severe complications in immunocompromised individuals and infants.

Introduction to Cytomegalovirus (CMV)

Cytomegalovirus (CMV) is a member of the Herpesviridae family and is recognized as the most common congenital viral infection in humans. Affecting nearly one in three children by age five and over half of adults by age 40, CMV infections can have severe implications on immunocompromised individuals, including patients with AIDS and recipients of solid organ and stem cell transplants.

Understanding CMV Infection

Most people infected with CMV exhibit no symptoms, making it challenging to identify the infection. When symptoms do occur, they include fever, fatigue, sore throat, and swollen glands. In some cases, CMV can cause mononucleosis or hepatitis (a liver problem). In immunocompromised individuals, CMV can cause more serious symptoms affecting the eyes, lungs, liver, esophagus, stomach, and intestines.

Infants born with CMV can experience brain, liver, spleen, lung, and growth problems. The most common long-term health problem in babies born with congenital CMV infection is hearing loss, which may be detected soon after birth or develop later in childhood.

Diagnosing CMV Infection

For healthy individuals, blood tests are used to diagnose CMV infection. However, for newborns, tests of saliva or urine are preferred. For infants with signs of congenital CMV infection at birth, antiviral medications like valganciclovir may improve hearing and developmental outcomes.

The Age of Advanced Diagnostics: DiAGSure CMV RT-PCR Detection Kit

The DiAGSure CMV RT-PCR Detection kit leverages the power of polymerase chain reaction (PCR) to detect the presence of CMV DNA in test samples. PCR is a highly sensitive method for detecting CMV, based on the amplification of nucleic acids.

The quantitative PCR (Real-Time PCR) method used in the DiAGSure kit allows for continuous monitoring of immunocompromised individuals, identifying patients at high risk for CMV disease and determining their response to antiviral treatment.

Detection of CMV in Congenital Infections

The traditional method for detecting CMV in congenital infections is through conventional cell culture. However, this method is slow and requires 2–3 weeks until a result can be reported as negative.

The DiAGSure CMV RT-PCR Detection kit, on the other hand, provides a rapid and accurate means of detecting congenital CMV infection.

Maternal and Fetal Infections

Primary maternal CMV infections are more likely to transmit to the fetus, occurring in 30–40% of primary maternal CMV infections. However, unlike toxoplasmosis and rubella, preconceptional immunity to CMV is not complete, and intrauterine transmission can occur in women who were previously CMV seroimmune.

PCR for Effective CMV Detection

PCR for CMV DNA can either be qualitative or quantitative. The quantitative PCR (Real-Time PCR) used in the DiAGSure CMV RT-PCR Detection kit allows for continuous monitoring of immunocompromised individuals. This method is rapid, can be automated, and results are usually reported as the number of copies/ml of blood or plasma.

A New Age in CMV Detection

The introduction of the DiAGSure CMV RT-PCR Detection kit marks a new age in the detection and diagnosis of CMV. It offers a rapid, reliable, and relatively inexpensive method for the detection of CMV, which can significantly improve patient outcomes.


The healthcare landscape is evolving, and the introduction of advanced diagnostic tools like the DiAGSure CMV RT-PCR Detection kit is a testament to this progress. Leveraging the power of PCR, this kit offers a rapid and reliable means of detecting CMV, thus improving patient care and outcomes.

As we continue to innovate and improve, healthcare professionals and patients alike can look forward to more accurate, faster, and more cost-effective diagnostic tools in the future. With these advancements, we move one step closer to a world where diseases like CMV can be detected and treated effectively, improving the quality of life for countless individuals.


[1] Journal of Clinical Microbiology. 2000 Jul; 38(7): 2734–2737.

[2] Centers for Disease Control and Prevention. Cytomegalovirus (CMV) and Congenital CMV Infection.

[3] Infect Disord Drug Targets. Author manuscript; available in PMC 2013 Aug 1.



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